Emerging treatment modalities for advanced pancreatic neuroendocrine tumors.

It was with great interest that we read the article titled “Neoadjuvant therapy for advanced pancreatic neuroendocrine tumors: an emerging treatment modality?” by I. Perysinakis et al published in the first issue of 2016 of the Journal.1 The authors review the recent literature concerning advanced pancreatic neuroendocrine tumors (pNETs) and highlight the fact that there is increasing evidence supporting the application of neoadjuvant protocols in this set of patients aiming at tumor downsizing to render curative surgery feasible.